Details on Vardict, a new variant caller, have been published recently in Nucleic Acids Research by authors, Zhongwu Lai and Jonathan Dry, among others from AstraZeneca . The current version of the Bina Read Alignment Variant Calling and Expression software module for secondary analysis includes Vardict, along with five other tools, for calling SNVs or indels from tumor-normal pairs. As the article demonstrates, VarDict has multiple strengths that extend our capabilities in variant calling beyond what was available before its release. Notably, the algorithm is particularly good at detecting indels. It also handles ultra-deep sequenced samples, which have become more common of late, and supports variant calling in tumor-only samples (in addition to tumor-vs-normal calling).
Topics: DREAM Challenge Results, Somatic Mutation Detection, Tumor-Normal, Webinar, Bina RAVE, SomaticSeq, AstraZeneca, Sequencing, VarScan, JointSNVMix, SomaticIndelDetector, VarDict, MuTect, SomaticSniper
With Bio-IT World Conference & Expo approaching, one of the traditions that attendees and sponsors look forward to is the award ceremony that recognizes outstanding technology innovators and research collaborations. Last year Bina beat out numerous contenders and was crowned winner of the Best of Show Award for the Genetic Analysis category. This year we have our eye on the prize for the Best Practices Award, and are honored to be amongst the 17 finalists that were recently selected. Winners will be announced during the Bio-IT plenary session on April 6 at 9:30 am.